Respuesta :
Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population.
At single-cell resolution, the heterogeneity between patients and within tumors hasn't been addressed. In this study, we used 125,674 cells from seven stage-I/II LUAD cases with EGFR mutations and five lung tissues around the tumor to perform single-cell RNA sequencing (Sc RNA-seq). We discovered a variety of cell types in the tumor microenvironment (TME), but the most prevalent stromal cell types in lung tumors and surrounding tissues were myeloid cells and T cells. Tumor-associated macrophages (TAMs) demonstrated pro-tumoral behaviors within tumors, accompanied by an increase in CD1C+ dendritic cells, but lacked identified M1 or M2 polarization hallmark gene expression. T cells that have invaded tumors predominantly exhibited regulatory and exhausted T-cell characteristics. Based on their gene expression profiles in several pathways such hypoxia, glycolysis, cell metabolism, translation initiation, cell cycle, and antigen presentation, adenocarcinoma cells may be divided into many subtypes.
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