Individuals that are heterozygous for a deletion of a locus on chromosome 11 show severe developmental disorders and growth abnormalities, but only when the deletion is inherited from the mother. The cause of these phenotypes has been localized to a promoter sequence located within a CpG island.
What epigenetic mark would you predict to be found on this imprinted promoter?

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30-11-2022
Biology

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Individuals that are heterozygous for a deletion of a locus on chromosome 11 show severe developmental disorders and growth abnormalities, but only when the deletion is inherited from the mother. The cause of these phenotypes has been localized to a promoter sequence located within a CpG island.
What epigenetic mark would you predict to be found on this imprinted promoter?

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jaspreetsharma jaspreetsharma · Answer 1 · 2022-12-04T08:56:34+01:00

DNA methylation would be found on this imprinted prompter ,Dna is found in every body on the earth.

DNA methylation is a heritable epigenetic mark that involves DNA methyltransferases covalently transferring a methyl group to the C-5 position of the cytosine ring of DNA (DNMTs). 1. Cytidines are methylated in plants in both symmetrical (CG or CHG) and asymmetrical (CHH, where H is A, T, or C) contexts. A chemical reaction in the body that involves the addition of a small molecule known as a methyl group to DNA, proteins, or other molecules. The addition of methyl groups can change how certain molecules behave in the body. For example, methylation of a gene's DNA sequence may turn the gene off, preventing it from producing a protein.

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