To calculate the slope of a line that passes through two given points you have to use the following formula
[tex]m=\frac{y_1-y_2}{x_1-x_2}[/tex]Where
m is the slope
(x₁,y₁) are the coordinates of one of the points
(x₂,y₂) are the coordinates of the second point
For the points (-3,5) and (4,-3) you can calculate the slope as follows
[tex]m=\frac{-3-5}{4-(-3)}=\frac{-8}{4+3}=-\frac{8}{7}[/tex]The slope is -8/7