Nucleotides can only be joined in one way (5' to 3') by DNA polymerase.
DNA synthesis or replication takes place during the S phase of a cell cycle, which happens during interphase and comes before mitosis or meiosis.
The act of copying and duplicating a DNA molecule is known as DNA replication. The procedure is run in a semi-conservative manner.
Before dividing, cells must copy their DNA. This promotes successful inheritance of genetic features by giving each daughter cell a copy of the genome. The fundamental mechanism of DNA replication is similar across all organisms, making it a crucial operation.
Three models—conservative, semi-conservative, and dispersive—were put out for DNA replication. According to the conservative way of replication, freshly generated daughter strands and the parental DNA should both remain together.
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