RNA polymerase holoenzyme sub-units includes α (two copies), β, β' and ω sub-units. which is sigma factor plus the core enzyme ,composed of five sub-units-a2BB'w.
The sub-unit of bacterial RNA polymerase has implicated in all steps of transcription initiation, which includes promoter recognition and opening, priming of RNA synthesis. RNA polymerase is essential units of life which is found in all living organisms as well as many viruses.
The role of sigma factor is to recognize the promoter sequence. Holoenzyme is consist of RNA synthesis from sigma 70 specific bacterial and phage promoters.RNA polymerase ,principle factor for initiation of transcription in bacteria , the sigma sub-unit of RNA polymerase to form holoenzyme capable of promoter recognition.
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