When fat stores shrink, blood levels of leptin decrease triggering eating behavior increases.
How does leptin act in the body?
Adipocytes secrete the hormone leptin, which has appetite-suppressing properties. Leptin is produced by fat cells, and when it attaches to a receptor in the hypothalamus, a signal cascade that finally reduces appetite is triggered.
Which gene causes fat cells to secrete the hormone leptin?
The LEP gene provides instructions on how to manufacture leptin, a hormone that regulates body weight. According to their size, the body's fat cells normally secrete leptin. As fat accumulates inside of cells, more leptin is produced.
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