In a germline mutation, the change occurs during the dna replication that precedes meiosis.
A gene change in a body's reproductive cell (egg or sperm) that becomes integrated into the DNA of every cell in the body of the offspring. Germline mutations are passed on from parents to offspring. Germline mutations are the cause of many diseases like, cystic fibrosis and cancer (eg, breast and ovarian cancer, melanoma). Cystic fibrosis is a hereditary genetic disorder that results in a thick, sticky buildup of mucus in the lungs, pancreas and other organs.
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