Pyruvate is the product of glycolysis, and after it moves into the mitochondrial matrix, it is oxidized to form acetyl COA, which enters the Krebs cycle.
- Glycolysis generates pyruvate in the cytoplasm, while the mitochondrial matrix is where pyruvate oxidation occurs (in eukaryotes).
- Pyruvate must therefore enter the mitochondrion, pass through its inner membrane, and reach the matrix before the chemical processes can start.
- The pyruvate molecules generated at the conclusion of glycolysis are carried into mitochondria, which are locations of cellular respiration, in eukaryotic cells.
- Aerobic respiration will continue if there is oxygen available. By eliminating a carbon dioxide molecule, pyruvate is converted in the mitochondria into a two-carbon acetyl group, which is then taken up by a carrier substance called coenzyme A (CoA), which is created from vitamin B5.
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