The individuals who have purebred dominant genotype would be at a disadvantage in an area with a high prevalence of malaria.
What do you mean by Malaria?
Malaria may be defined as a disease that is caused by the plasmodium parasite and may spread to the people through the bites of a female mosquito Anopheles.
Those individuals who have the genotype purebred dominant (AA) produce normal red blood cells, while the individual who has the genotype purebred recessive (aa) possess sickle cell condition. The normal red blood cells are immaculate hosts for the infection of malaria.
Therefore, the individuals who have purebred dominant genotype would be at a disadvantage in an area with a high prevalence of malaria.
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