A lipid-soluble hormone binds to its intracellular receptor and then binds to a portion of DNA called a hormone-response element (HRE). It is fundamental to activate signaling pathways.
A hormone response element (HRE) is a short nucleotide sequence capable of binding a hormone-receptor complex.
Hormone response elements are located in the promoter gene regions where they function to activate transcription.
The activation of transcription by means of a hormone response element leads to the activation of a given signaling pathway.
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