Anemia of chronic disease is immune driven; cytokines and cells of the reticuloendothelial
system induce changes in iron homeostasis, the proliferation of erythroid progenitor
cells, the production of erythropoietin, and the life span of red cells, all of which
contribute to the pathogenesis of anemia
Anemia with chronic kidney disease shares some of the characteristics of anemia of
chronic disease, although the decrease in the production of erythropoietin, mediated by
renal insufficiency and the antiproliferative effects of accumulating uremic toxins, contribute
importantly
hope this helps
