Which of the following statements describes the interaction of water molecules with phospholipids? Which of the following statements describes the interaction of water molecules with phospholipids? The polar heads avoid water; the nonpolar tails attract water (because water is polar and opposites attract). The polar heads interact with water; the nonpolar tails do not. Phospholipids do not interact with water because water is polar and lipids are nonpolar. Phospholipids dissolve in water.