Respuesta :
Glycogen
Explanation:
- This is based on the fact that the response to hormones generates a signaling cascade that eventuates in the activation or inhibition of enzymes involved in glycogen metabolism
- The benefit of a multi-step cascade is that it amplifies the signal which means that response can be fast and significant
- High level of secondary messenger, cyclic adenosine monophosphate (cAMP) activates a protein called protein kinase A (pKA) which phosphorylates phosphorylase kinase (pK) and activates it
- On the other hand at the same time pKA phosphorylates glycogen synthase and inactivate it
- pK becomes active that phosphorylates glycogen phosphorylase and makes it active, glycogen phosphorylase catalyse breakdown of glycogen (in liver and muscle cells)
- Activated protein kinase A enters in nucleus and phosphorylate a transcriptional activator called cyclic AMP response element binding protein (CREB)
- Phosphorylated CREB becomes active and binds to a DNA element called cyclic AMP response element (CRE) and induce transcription of various genes which involved in glucose metabolism
