A 34-year-old woman with ulcerative colitis has required long-term treatment with pharmacologic doses of a glucocorticoid agonist. Which of the following is a toxic effect associated with long-term glucocorticoid treatment?

(A) A lupus-like syndrome

(B) Adrenal gland neoplasm

(C) Hepatotoxicity

(D) Osteoporosis

(E) Precocious puberty in children