What is the probability that a female child of Charles and Marie would suffer from hemophilia?
0 percent
25 percent
50 percent
100 percent

Respuesta :

Answer:

The correct option is A) zero percent

Explanation:

Hemophilia can be described as an X-linked recessive disorder in which the blood of a person is not able to clot properly. As it is a recessive disorder, both the alleles should be recessive for the disorder to occur. In males, as only one X chromosome is present hence, only one allele would be enough to cause the disorder in males. Whereas for females, both the X chromosomes will have to carry the recessive type alleles for the disorder to occur.

Hemophilia is an X-linked recessive disease. The probability that a female child would suffer from hemophilia is 0% if at least one of the parental genotypes carries the dominant allele, X⁺.

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We know that Hemophilia is an X-linked recessive disorder.

We will say that the X chromosome with the recessive allele is X⁻, while the X chromosome with the dominant allele is X⁺.

Since I do not have the genotypes of Charles and Marie, I will provide different pottential scenarios.

Scenario 1)

  • Charles : X⁻Y
  • Marie :  X⁺X⁺

Parentals)   X⁺X⁺    x     X⁻Y

Gametes)  X⁺     X⁺       X⁻    Y

Punnett square)     X⁺        X⁺

                     X⁻    X⁺X⁻   X⁺X⁻

                     Y      X⁺Y     X⁺Y

F1)   0% of the progeny will suffer from hemophilia

The probability that a female child of Charles and Marie would suffer from hemophilia is 0%.

   

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Scenario 2)

  • Charles : X⁻Y
  • Marie :  X⁺X⁻

Parentals)   X⁺X⁻    x     X⁻Y

Gametes)  X⁺     X⁻       X⁻    Y

Punnett square)     X⁺        X⁻

                     X⁻    X⁺X⁻   X⁻X⁻

                     Y      X⁺Y     X⁻Y

F1)   50% of the progeny will suffer from hemophilia

The probability that a female child of Charles and Marie would suffer from hemophilia is 50% (1/2) considering only females, and 25% (1/4) considering the whole progeny.

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Scenario 3)

  • Charles : X⁻Y
  • Marie :  X⁻X⁻

Parentals)   X⁻X⁻    x     X⁻Y

Gametes)  X⁻     X⁻       X⁻    Y

Punnett square)     X⁻        X⁻

                     X⁻    X⁻X⁻   X⁻X⁻

                     Y      X⁻Y     X⁻Y

F1)   100% of the progeny will suffer from hemophilia

The probability that a female child of Charles and Marie would suffer from hemophilia is 100%

****************************

Scenario 4)

  • Charles : X⁺Y
  • Marie :  X⁻X⁻

Parentals)   X⁻X⁻    x     X⁺Y

Gametes)  X⁻     X⁻       X⁺   Y

Punnett square)     X⁻        X⁻

                     X⁺    X⁺X⁻   X⁺X⁻

                     Y      X⁻Y     X⁻Y

F1)   50% of the progeny will suffer from hemophilia

The probability that a female child of Charles and Marie would suffer from hemophilia is 0%

****************************

Scenario 5)

  • Charles : X⁺Y
  • Marie :  X⁺X⁻

Parentals)   X⁺X⁻    x     X⁺Y

Gametes)  X⁺     X⁻       X⁺   Y

Punnett square)     X⁺        X⁻

                     X⁺    X⁺X⁺   X⁺X⁻

                     Y      X⁺Y     X⁻Y

F1)   25% of the progeny will suffer from hemophilia

The probability that a female child of Charles and Marie would suffer from hemophilia is 0%.

****************************

Scenario 6)

  • Charles : X⁺Y
  • Marie :  X⁺X⁺

Parentals)   X⁺X⁺    x     X⁺Y

Gametes)  X⁺     X⁺       X⁺   Y

Punnett square)     X⁺        X⁺

                     X⁺    X⁺X⁺   X⁺X⁺

                     Y      X⁺Y     X⁺Y

F1)   0% of the progeny will suffer from hemophilia

The probability that a female child of Charles and Marie would suffer from hemophilia is 0%.

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