The human gene EGFR located on chromosome 7 is a proto-oncogene that codes for a growth factor cell surface receptor. The binding of growth factors to this receptor can lead to cell proliferation. Hypothesize what potential impact a mutated EGFR allele will have on a cell. Give one possible impact and explain your answer

The proto-oncogenes when mutated will have the ability to cause cancer, as the proto-oncogenes will become permanently activated by the mutation. Most probably they will cause the growth factors which bind to it to have rapid, abnormal divisions which will lead to cancer. The uncontrollable cell division will cause cancer. Hence, turning the normal proto-oncogenes into oncogenes or cancerous genes.

Diatonic254 Diatonic254 · Answer 2 · 2019-12-06T07:58:35+01:00

Explanation:

A mutated EGFR may cause the cells of the body to bear malfunctioned growth factor cell receptors. These receptors may be unable to bind growth factors that signal the cell to divide and grow. Therefore an organism bearing a mutated EGFR may have stunted growth.

On the other hand, the mutated EGFR may cause the growth factor cell receptors to permanently bind growth factors. This would cause the cells to proliferated unregulated hence causing unchecked growth. This can cause tumors in the organism or excessive growth.

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