The role of helicase in DNA replication is option C. Helicase breaks the hydrogen bonds and unwinds a section of DNA.
What role does helicase play in DNA replication?
- DNA helicase is an ATP-dependent catalytic enzyme that unwinds the dsDNA for providing leading as well as lagging strand replication.
- It runs ahead of the replication fork and continuously unwinds the dsDNA, providing the template for DNA polymerase to work.
- Unwinding the double-stranded nucleic acid (DNA/RNA) is a major function of any helicase subclass enzyme.
- In DNA replication, the helicase works by creating a complex with other proteins such as DNA primase, polymerase, or single-stranded-binding proteins.
- During replication, the helicase unwinds the dsDNA as we discussed above.
- Apart from this, several other functions are also performed by the helicase which is enlisted below,
- During DNA repair, the helicase unwinds or opens the dsDNA for repairing damaged DNA strands.
- During the translation, it breaks the hydrogen bonds between the DNA-RNA hybrid.
The correct option exists C because Helicase stands for the enzyme that unwinds the DNA by breaking hydrogen bonds between the two strands and creating a replication fork.
Hence, option C. Helicase breaks the hydrogen bonds and unwinds a section of DNA.
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