Which statement by the nursing student regarding the pharmacokinetic parameters of lubiprostone requires further intervention?"Lubiprostone has low systemic availability with oral administration.""The drug is 94% protein bound with minimal distribution outside of the gastrointestinal (GI) tract.""Lubiprostone is quickly metabolized in the stomach and jejunum by the cytochrome P450 (CYP450) system.""The drug is excreted mostly in urine and some in feces."